Article Excerpt: The new implantable device was found to accurately detect physiologic changes linked with opioid overdose and facilitate effective naloxone administration. The implantation site was selected for the s.c. space because it reduced mechanical irritation after implantation. The implanted device lasts up to 16 days, and naloxone remains stable at body temperature for over two weeks. Although the implantable device is large, it facilitates data collection that aids in closed-loop decision-making for opioid overdose management. The swine model demonstrated that the iSOS implant was able to detect both rapid opioid overdose with apnea and gradual opioid poisoning with hypopnea. For both instances, naloxone was effectively administered. Conceptually, this device can be easily implanted in patients who are at a higher risk of an opioid overdose at a clinic through local anesthesia. At subsequent follow-up visits, the device can be wirelessly recharged, and the naloxone reservoir replenished, if required.
Full Article: https://tinyurl.com/25hhbhhd
Article Source: News-Medical.Net